In the field of marine pharmacognosy, PBA has developed a series of methodologies for screening microalgae species and molecules, notably using a dereplication tool (CHLP/UV-DAD) dedicated to pigment analysis. This particular method is adept at drawing up pigment profiles specific to each group of species and to their physiological state, but is useful above all for detecting the presence of original pigments. This laboratory research aims to study one area of microalgae metabolomics by processing imprint data in a similar manner to the methods recently developed in proteomics and transcriptomics.
The PHOTOMER project is funded by the ANR, the Pays-de-la-Loire region, the Cancéropôle Grand Ouest and the French anti-cancer League, and aims to find pigments or ‘photosensibilisers’ derived from microalgae with a view to their being used in photodynamic cancer treatments (PDT). In the framework of this project, a partnership between the PBA laboratory and the Laser department of the CHU Läennec - Nantes has enabled isolation of several extracts. The performances of these extracts under laboratory conditions are 10-30 times higher than those of the best molecule currently on the market.